Water → HCID 23368332, compound

HRID 1901545Notes

Reaction equation

HRID 1901545 reaction equation
[I:1][C:2]#[C:3][CH2:4][O:5][C:6]1[C:10]([C:11]#[N:12])=[C:9](S(C)(=O)=O)[S:8][N:7]=1.[CH3:17][O-:18].[Na+].O>CO>[I:1][C:2]#[C:3][CH2:4][O:5][C:6]1[C:10]([C:11]#[N:12])=[C:9]([O:18][CH3:17])[S:8][N:7]=1

Participants

5

Reactant 3

HCID 962WaterHCID 10942334Sodium MethoxideHCID 23368324HCID 23368324, compound

Product 1

HCID 23368332HCID 23368332, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3.6 Grams of 3-(3-iodo-2-propynyloxy)-4-cyano5-methylsulfonylisothiazole synthesized in Example 2 was dissolved in 30 ml of methanol, 0.6 g of sodium methoxide was added thereto, and then the reaction solution was stirred at room temperature for 4 hours. Water was added to precipitate crystals, which were then collected by filtration, washed with water, dried and recrystallized from ether. Thus, 2.4 g of crystals having a melting point of 159° to 160° C. (yield 78%) was obtained.

Workup

  1. customto precipitate crystals, which
  2. filtrationwere then collected by filtration
  3. washwashed with water
  4. customdried
  5. customrecrystallized from ether
  6. customwas obtained

Sources & evidence

ORD record
ord-b68eef35d9c94f6cae15d5a9248b97c6
Source dataset
uspto-grants-1996_11
Patent number
US05578622

Reaction notes

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