Water → HCID 23368332, compound

Participants

Reaction Steps

3.6 Grams of 3-(3-iodo-2-propynyloxy)-4-cyano5-methylsulfonylisothiazole synthesized in Example 2 was dissolved in 30 ml of methanol, 0.6 g of sodium methoxide was added thereto, and then the reaction solution was stirred at room temperature for 4 hours. Water was added to precipitate crystals, which were then collected by filtration, washed with water, dried and recrystallized from ether. Thus, 2.4 g of crystals having a melting point of 159° to 160° C. (yield 78%) was obtained.

Provenance & Evidence