Trifluoroacetic acid → HCID 22862373, compound

HRID 1901590Notes

Reaction equation

HRID 1901590 reaction equation
[C:1]([C@@H:5]([NH:10][C:11](=[O:28])[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH:18](C(OC(C)(C)C)=O)[NH:19][CH3:20])[CH:13]=1)[CH2:6][CH2:7][S:8][CH3:9])([O:3][CH3:4])=[O:2].[F:29][C:30]([F:35])([F:34])[C:31]([OH:33])=[O:32]>C(Cl)Cl>[F:29][C:30]([F:35])([F:34])[C:31]([OH:33])=[O:32].[C:1]([C@@H:5]([NH:10][C:11](=[O:28])[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][NH:19][CH3:20])[CH:13]=1)[CH2:6][CH2:7][S:8][CH3:9])([O:3][CH3:4])=[O:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22862377HCID 22862377, compound

Product 1

HCID 22862373HCID 22862373, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of the product from Step G in methylene chloride was added trifluoroacetic acid (33% by volume). After stirring for 1 h the solution was concentrated in vacuo to yield the title compound.

Workup

  1. concentrationwas concentrated in vacuo

Sources & evidence

ORD record
ord-377bfd92c2d84593a9c15c679a151cf3
Source dataset
uspto-grants-1996_11
Patent number
US05578629

Reaction notes

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