HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(2-Amino-3-hydroxypropoxy)-5-chloro-1,2-benzoisoxazole hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 3-(2-Amino-3-hydroxypropoxy)-5-chloro-1,2-benzoisoxazole | HCID 15382580 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-(2-Amino-3-hydroxypropoxy)-5-chloro-1,2-benzoisoxazole hydrochloride | HCID 23368494 | — |
Reaction Steps
To a solution of 4.13 g of 3-(2-amino-3-hydroxypropoxy)-5-chloro-1,2-benzoisoxazole in 82 ml of ethyl acetate is added 13.6 ml of a dioxane solution (2.2N) of hydrogen chloride, and the crystals precipitated are collected by filtration to obtain 4.52 g of colorless, crystalline 3-(2-amino-3-hydroxypropoxy)-5-chloro-1,2-benzoisoxazole hydrochloride having a melting point of 216°-217° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05578627 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-f1891898f65e4b04af4d5e20b3d3a121 |
| Source note | uspto-grants-1996_11 |