Hydrochloric Acid → 3-(2-Amino-3-hydroxypropoxy)-5-chloro-1,2-benzoisoxazole hydrochloride

HRID 1901595Notes

Reaction equation

HRID 1901595 reaction equation
[NH2:1][CH:2]([CH2:15][OH:16])[CH2:3][O:4][C:5]1[C:9]2[CH:10]=[C:11]([Cl:14])[CH:12]=[CH:13][C:8]=2[O:7][N:6]=1.O1CCOCC1.Cl>C(OCC)(=O)C>[ClH:14].[NH2:1][CH:2]([CH2:15][OH:16])[CH2:3][O:4][C:5]1[C:9]2[CH:10]=[C:11]([Cl:14])[CH:12]=[CH:13][C:8]=2[O:7][N:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 153825803-(2-Amino-3-hydroxypropoxy)-5-chloro-1,2-benzoisoxazole

Product 1

HCID 233684943-(2-Amino-3-hydroxypropoxy)-5-chloro-1,2-benzoisoxazole hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 4.13 g of 3-(2-amino-3-hydroxypropoxy)-5-chloro-1,2-benzoisoxazole in 82 ml of ethyl acetate is added 13.6 ml of a dioxane solution (2.2N) of hydrogen chloride, and the crystals precipitated are collected by filtration to obtain 4.52 g of colorless, crystalline 3-(2-amino-3-hydroxypropoxy)-5-chloro-1,2-benzoisoxazole hydrochloride having a melting point of 216°-217° C.

Workup

  1. customthe crystals precipitated
  2. filtrationare collected by filtration

Sources & evidence

ORD record
ord-f1891898f65e4b04af4d5e20b3d3a121
Source dataset
uspto-grants-1996_11
Patent number
US05578627

Reaction notes

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