Ethyl Acetate → HCID 23368520, compound

Participants

Reaction Steps

To a solution of 0.39 g of 3-(2-amino-3-hydroxypropoxy)-5-methyl-1,2-benzoisoxazole hydrochloride in 4 ml of water is added 4 ml of ethyl acetate, and the pH is adjusted to 11 with 10% (w/w) aqueous sodium hydroxide solution, after which the organic layer is separated. The separated organic layer is washed with a saturated saline solution and dried over anhydrous magnesium sulfate, after which the solvent is removed by distillation under reduced pressure to obtain 0.32 g of colorless, solid 3-(2-amino-3-hydroxypropoxy)-5-methyl-1,2-benzoisoxazole.

Provenance & Evidence