Ethyl Acetate → HCID 23368520, compound

HRID 1901598Notes

Reaction equation

HRID 1901598 reaction equation
Cl.[NH2:2][CH:3]([CH2:16][OH:17])[CH2:4][O:5][C:6]1[C:10]2[CH:11]=[C:12]([CH3:15])[CH:13]=[CH:14][C:9]=2[O:8][N:7]=1.C(OCC)(=O)C.[OH-].[Na+]>O>[NH2:2][CH:3]([CH2:16][OH:17])[CH2:4][O:5][C:6]1[C:10]2[CH:11]=[C:12]([CH3:15])[CH:13]=[CH:14][C:9]=2[O:8][N:7]=1

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 14798Sodium HydroxideHCID 23368530HCID 23368530, compound

Product 1

HCID 23368520HCID 23368520, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 0.39 g of 3-(2-amino-3-hydroxypropoxy)-5-methyl-1,2-benzoisoxazole hydrochloride in 4 ml of water is added 4 ml of ethyl acetate, and the pH is adjusted to 11 with 10% (w/w) aqueous sodium hydroxide solution, after which the organic layer is separated. The separated organic layer is washed with a saturated saline solution and dried over anhydrous magnesium sulfate, after which the solvent is removed by distillation under reduced pressure to obtain 0.32 g of colorless, solid 3-(2-amino-3-hydroxypropoxy)-5-methyl-1,2-benzoisoxazole.

Workup

  1. customafter which the organic layer is separated
  2. washThe separated organic layer is washed with a saturated saline solution
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customafter which the solvent is removed by distillation under reduced pressure

Sources & evidence

ORD record
ord-e093157b9ca7442abcb229d79bfb5345
Source dataset
uspto-grants-1996_11
Patent number
US05578627

Reaction notes

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