HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(2-Amino-3-methoxypropoxy)-5-chloro-1,2-benzoisoxazole hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 5-Chloro-3-(3-methoxy-2-tritylaminopropoxy)-1,2-benzoisoxazole | HCID 23368517 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 3-(2-Amino-3-methoxypropoxy)-5-chloro-1,2-benzoisoxazole hydrochloride | HCID 23368555 | — |
Reaction Steps
To a suspension of 5-chloro-3-(3-methoxy-2-tritylaminopropoxy)-1,2-benzoisoxazole in 49 ml of 2-propanol is added 1.5 ml of a 2-propanol solution (7.5N) of hydrogen chloride, and they are refluxed for ten minutes, after which the crystals are collected by filtration, to obtain 2.34 g of colorless, crystalline 3-(2-amino-3-methoxypropoxy)-5-chloro-1,2-benzoisoxazole hydrochloride having a melting point of 200°-202° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05578627 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-445100eb2a8a4b369b7956b12240f9c5 |
| Source note | uspto-grants-1996_11 |