Hydrochloric Acid → 3-(2-Amino-3-methoxypropoxy)-5-chloro-1,2-benzoisoxazole hydrochloride

HRID 1901602Notes

Reaction equation

HRID 1901602 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][N:8]=[C:7]([O:10][CH2:11][CH:12]([NH:16]C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH2:13][O:14][CH3:15])[C:6]=2[CH:36]=1.Cl>CC(O)C>[ClH:1].[NH2:16][CH:12]([CH2:13][O:14][CH3:15])[CH2:11][O:10][C:7]1[C:6]2[CH:36]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=2[O:9][N:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 233685175-Chloro-3-(3-methoxy-2-tritylaminopropoxy)-1,2-benzoisoxazole

Product 1

HCID 233685553-(2-Amino-3-methoxypropoxy)-5-chloro-1,2-benzoisoxazole hydrochloride

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent2×

Procedure

To a suspension of 5-chloro-3-(3-methoxy-2-tritylaminopropoxy)-1,2-benzoisoxazole in 49 ml of 2-propanol is added 1.5 ml of a 2-propanol solution (7.5N) of hydrogen chloride, and they are refluxed for ten minutes, after which the crystals are collected by filtration, to obtain 2.34 g of colorless, crystalline 3-(2-amino-3-methoxypropoxy)-5-chloro-1,2-benzoisoxazole hydrochloride having a melting point of 200°-202° C.

Workup

  1. temperatureare refluxed for ten minutes
  2. filtrationafter which the crystals are collected by filtration

Sources & evidence

ORD record
ord-445100eb2a8a4b369b7956b12240f9c5
Source dataset
uspto-grants-1996_11
Patent number
US05578627

Reaction notes

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