Hydrochloric Acid → HCID 23368420, compound

Participants

Reaction Steps

To a solution of 0.30 g of 3-[2-tert-butoxycarbonylamino-3-(3-pyridyloxy)propoxy]-1,2-benzoisoxazole in 5 ml of methanol is added 1 ml of a dioxane solution (3.2N) of hydrogen chloride at room temperature, and they are subjected to reaction at the same temperature for two hours, after which the crystals precipitated are collected by filtration, to obtain 0.24 g of colorless, crystalline 3-[2-amino-3-(3-pyridyloxy)propoxy]-1,2-benzoisoxazole dihydrochloride having a melting point of 216.8°-218.9° C. (decomp.).

Provenance & Evidence