Hydrochloric Acid → HCID 23368420, compound

HRID 1901659Notes

Reaction equation

HRID 1901659 reaction equation
C(OC([NH:8][CH:9]([CH2:21][O:22][C:23]1[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=1)[CH2:10][O:11][C:12]1[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[O:14][N:13]=1)=O)(C)(C)C.O1CCOCC1.[ClH:35]>CO>[ClH:35].[ClH:35].[NH2:8][CH:9]([CH2:21][O:22][C:23]1[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=1)[CH2:10][O:11][C:12]1[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[O:14][N:13]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 23368445HCID 23368445, compound

Product 1

HCID 23368420HCID 23368420, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 0.30 g of 3-[2-tert-butoxycarbonylamino-3-(3-pyridyloxy)propoxy]-1,2-benzoisoxazole in 5 ml of methanol is added 1 ml of a dioxane solution (3.2N) of hydrogen chloride at room temperature, and they are subjected to reaction at the same temperature for two hours, after which the crystals precipitated are collected by filtration, to obtain 0.24 g of colorless, crystalline 3-[2-amino-3-(3-pyridyloxy)propoxy]-1,2-benzoisoxazole dihydrochloride having a melting point of 216.8°-218.9° C. (decomp.).

Workup

  1. customthey are subjected to reaction at the same temperature for two hours
  2. customafter which the crystals precipitated
  3. filtrationare collected by filtration

Sources & evidence

ORD record
ord-0ef9c6578ac84e62bb5e01662460f632
Source dataset
uspto-grants-1996_11
Patent number
US05578627

Reaction notes

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