反应详情

Following a procedure similar to that described in Example 4, 300 mg of 5-{4-[2-(3-phenyl-2-hydroxypropylamino)propoxy]benzyl}thiazolidine-2,4-dione (prepared as described in Example 7), 120 mg of N,N'-carbonyldiimidazole and 10 ml of anhydrous dimethylformamide were used. The resulting crude product was applied to a silica gel chromatography column, which was then eluted with a 3:2 by volume mixture of ethyl acetate and hexane, to give 200 mg of the title compound, melting at 60° C. to 70° C.

1. washwas then eluted with a 3:2 by volume mixture of ethyl acetate and hexane