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HRID1901807

反应详情

EQUATION

反应方程式

HRID 1901807 的结构方程式

REACTANTS

反应物

2
结构：C1CCC2=NCCCN2CC1
HCID81184

1,8-Diazabicyclo[5.4.0]undec-7-ene

C9H16N2

结构：Cc1ccc(S(=O)(=O)N(CC(=O)N(C)C)c2ccc(Cl)cc2C(=O)C2CCCCC2)cc1
HCID54361654

未命名化合物

PRODUCTS

生成物

1
结构：Cc1ccc(S(=O)(=O)N2c3ccc(Cl)cc3C(O)(C3CCCCC3)C2C(=O)N(C)C)cc1
HCID23368623

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

1.5 g of the product obtained in step C are treated with 950 mg of DBU in 10 ml of DCM for 24 hours at RT. The reaction medium is then chromatographed on silica using a DCM/AcOEt mixture (95/5, v/v) as the eluent to give the other isomer (cis isomer). It is recrystallized from isopropyl ether.

WORKUP

后处理

  1. customThe reaction medium is then chromatographed on silica using a DCM/AcOEt mixture (95/5
  2. customv/v) as the eluent to give the other isomer (cis isomer)
  3. customIt is recrystallized from isopropyl ether