HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Spiro[1H-indene-1,4'-piperidin]-3(2H)-one trifluoroacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Anisole | HCID 7519 | — |
| Reactant | 1'-(t-butyloxycarbonyl)-3,4-dihydro-3-oxospiro[1H-indene-1,4'-piperidine] | HCID 19030439 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Spiro[1H-indene-1,4'-piperidin]-3(2H)-one trifluoroacetamide | HCID 18467060 | — |
Reaction Steps
A solution of the intermediate from Step A in a 1:1:0.5 mixture of trifluoroacetic acid, dichloromethane and anisole was stirred for 1 hour and then concentrated and azeotroped from toluene to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05578593 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-23a0414e077d4226beee648f0b9d5abe |
| Source note | uspto-grants-1996_11 |