Hydrochloric Acid → HCID 22867366, compound

HRID 1902154Notes

Reaction equation

HRID 1902154 reaction equation
[N:1]1([C:15]([C@H:17]([NH:27][C:28](=[O:37])[C:29]([NH:32][CH2:33][C@H:34]([OH:36])[CH3:35])([CH3:31])[CH3:30])[CH2:18][O:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[O:16])[CH2:6][CH2:5][C:4]2([C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[CH2:8][CH2:7]2)[CH2:3][CH2:2]1.[ClH:38]>CC(O)=O>[ClH:38].[N:1]1([C:15]([C@H:17]([NH:27][C:28](=[O:37])[C:29]([NH:32][CH2:33][C@H:34]([OH:36])[CH3:35])([CH3:30])[CH3:31])[CH2:18][O:19][CH2:20][C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)=[O:16])[CH2:6][CH2:5][C:4]2([C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[CH2:8][CH2:7]2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22867365HCID 22867365, compound

Product 1

HCID 22867366HCID 22867366, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a solution of 20 mg of N-[1(R)-[(2,3-dihydrospiro[1H-indene-1,4'-piperidin]-1'-yl)carbonyl]-2-(phenylmethyloxy)ethyl]-2-(2-(R)-hydroxypropyl)amino-2-methylpropanamide (0.04 mmoles) in 1 mL of HOAc was added 0.01 mL of conc. HCl (0.12 mmoles), and the solution lyophyllized over night to give the title compound. Calc. for C30H41N3O4 +HCl:MW=507.7+HCl; found m/e=(m+1) 509.4.

Workup

  1. waitthe solution lyophyllized over night

Sources & evidence

ORD record
ord-07aabe59ee0940dfa3f63f790f15f1fc
Source dataset
uspto-grants-1996_11
Patent number
US05578593

Reaction notes

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