Diethyl Ether → HCID 12892988, compound

HRID 1902180Notes

Reaction equation

HRID 1902180 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:13](=[O:14])[CH:12]3[CH2:15][CH2:16][CH2:17][C:10](=[CH:11]3)C2=O)=[CH:4][CH:3]=1.[CH3:19][NH:20][CH2:21][CH2:22][CH2:23][CH3:24].C[CH2:26][O:27]CC.B(F)(F)F>CC(C)=O>[CH3:19][N:20]([CH2:21][CH2:22][CH2:23][CH3:24])[C:26](=[O:27])[C:15]1[CH2:16][CH2:17][CH2:10][CH2:11][C:12]=1[C:13]([NH:8][C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)=[O:14]

Participants

6

Reactant 4

HCID 3283Diethyl EtherHCID 6356Boron trifluorideHCID 8068N-MethylbutylamineHCID 20515771HCID 20515771, compound

Product 1

HCID 12892988HCID 12892988, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

In 100 ml of acetone is dissolved 3.0 g of N-(4-chlorophenyl)-3,4,5,6-tetrahydroisophthalimide. To the solution is added 1.2 g of N-methyl-butylamine under stirring at room temperature, followed by adding further 0.025 ml of a 5% ether solution of boron trifluoride thereto. The solution is stirred for 1 hour, and then shaken with 100 ml of ice water.

Workup

  1. stirringThe solution is stirred for 1 hour

Sources & evidence

ORD record
ord-5861cfaab7724bd6b846c959f1b3ab00
Source dataset
uspto-grants-1982_12
Patent number
US04362546

Reaction notes

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