HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethylamine → N,N-diethyl-N'-(2-fluoro-4-chlorophenyl)-3,4,5,6-tetrahydrophthalamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethylamine | HCID 8021 | — |
| Reactant | 2-(4-Chloro-2-fluorophenyl)-4,5,6,7-tetrahydro-1h-isoindole-1,3(2h)-dione | HCID 185931 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | N,N-diethyl-N'-(2-fluoro-4-chlorophenyl)-3,4,5,6-tetrahydrophthalamide | HCID 12893023 | 56.6% |
Reaction Steps
In 50 ml of acetone is dissolved 2.8 g of N-(2-fluoro-4-chlorophenyl)-3,4,5,6-tetrahydrophthalimide. To the solution is added 0.8 g of diethylamine under stirring at room temperature. After further stirring for 30 minutes, the solution is concentrated to dryness under reduced pressure, followed by adding 50 ml of n-hexane to cool. The resultant crystals are recovered by filtration and recrystallized from n-hexane, to yield 2.0 g of the subject compound. Melting point: 105° C.-106° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04362546 |
| Source dataset | uspto-grants-1982_12 |
| ORD ID | ord-693e37d947c9459e8046f38b26fc7757 |
| Source note | uspto-grants-1982_12 |