反应详情

In 50 ml of acetone is dissolved 2.8 g of N-(2-fluoro-4-chlorophenyl)-3,4,5,6-tetrahydrophthalimide. To the solution is added 0.8 g of diethylamine under stirring at room temperature. After further stirring for 30 minutes, the solution is concentrated to dryness under reduced pressure, followed by adding 50 ml of n-hexane to cool. The resultant crystals are recovered by filtration and recrystallized from n-hexane, to yield 2.0 g of the subject compound. Melting point: 105° C.-106° C.

1. stirringAfter further stirring for 30 minutes
2. concentrationthe solution is concentrated to dryness under reduced pressure
3. additionby adding 50 ml of n-hexane
4. temperatureto cool
5. filtrationThe resultant crystals are recovered by filtration
6. customrecrystallized from n-hexane