Acetic Acid → Aptazapine

HRID 1902190Notes

Reaction equation

HRID 1902190 reaction equation
[CH3:1][N:2]1[C:19](=O)[C:18](=O)[N:5]2[C:6]3[CH:17]=[CH:16][CH:15]=[CH:14][C:7]=3[CH2:8][N:9]3[CH:13]=[CH:12][CH:11]=[C:10]3[CH:4]2[CH2:3]1.C(O)(=O)C>O1CCCC1.B#B>[CH3:1][N:2]1[CH2:19][CH2:18][N:5]2[C:6]3[CH:17]=[CH:16][CH:15]=[CH:14][C:7]=3[CH2:8][N:9]3[CH:13]=[CH:12][CH:11]=[C:10]3[CH:4]2[CH2:3]1

Participants

5

Reactant 2

HCID 176Acetic AcidHCID 128377152-methyl-3,4-dioxo-1,2,4,14b-tetrahydro-10H-pyrazino[1,2-a]pyrrolo[2,1-c][1,4]benzodiazepine

Product 1

HCID 51355Aptazapine

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolvent2×HCID 6328200DiboronSolvent

Procedure

To the suspension of 12.8 g of 2-methyl-3,4-dioxo-1,3,4,14b-tetrahydro-10H-pyrazino[1,2-a]pyrrolo[2,1-c][1,4]benzodiazepine in 460 ml of tetrahydrofuran, 200 ml of 1-molar diborane in tetrahydrofuran are added while stirring and cooling with ice. The mixture is refluxed for one hour, again cooled and combined with 25 ml of acetic acid. It is evaporated, the residue taken up in 50 ml of 30% aqueous sodium hydroxide and the mixture extracted with methylene chloride. The extract is dried, evaporated, the residue dissolved in diethyl ether, the solution filtered and the filtrate evaporated, to yield the 2-methyl-1,3,4,14b-tetrahydro-10H-pyrazino[1,2-a]pyrrolo[2,1-c][1,4]benzodiazepine.

Workup

  1. additionare added
  2. temperaturecooling with ice
  3. temperatureThe mixture is refluxed for one hour
  4. temperatureagain cooled
  5. customIt is evaporated
  6. extractionthe mixture extracted with methylene chloride
  7. customThe extract is dried
  8. customevaporated
  9. dissolutionthe residue dissolved in diethyl ether
  10. filtrationthe solution filtered
  11. customthe filtrate evaporated

Sources & evidence

ORD record
ord-d905523a2c1e4d0d9da26b1c5869361f
Source dataset
uspto-grants-1982_12
Patent number
US04362666

Reaction notes

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