Diboron → HCID 13103378, compound

HRID 1902198Notes

Reaction equation

HRID 1902198 reaction equation
[CH:1]([C:3]1[N:12]2[C:6]([CH:7]3[CH2:20][N:19]([CH3:21])[C:18](=O)[C:17](=O)[N:8]3[C:9]3[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=3[CH2:11]2)=[CH:5][CH:4]=1)=O.B#B>>[CH3:21][N:19]1[CH2:18][CH2:17][N:8]2[C:9]3[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=3[CH2:11][N:12]3[C:3]([CH3:1])=[CH:4][CH:5]=[C:6]3[CH:7]2[CH2:20]1

Participants

3

Reactant 2

HCID 6328200DiboronHCID 1283778412-formyl-2-methyl-3,4-dioxo-1,3,4,14b-tetrahydro-10H-pyrazino[1,2-a]pyrrolo[2,1-c][1,4]benzodiazepine

Product 1

HCID 13103378HCID 13103378, compound

Procedure

According to the method illustrated by Examples 1 and 2, the 12-formyl-2-methyl-3,4-dioxo-1,3,4,14b-tetrahydro-10H-pyrazino[1,2-a]pyrrolo[2,1-c][1,4]benzodiazepine is reduced with diborane, to yield the 2,12-dimethyl-1,3,4,14b-tetrahydro-10H-pyrazino[1,2-a]pyrrolo[2,1-c][1,4]benzodiazepine, which is converted into its monomaleate melting at 173°-175°.

Sources & evidence

ORD record
ord-59b3b9f0f84544b59e6b6fef7989814c
Source dataset
uspto-grants-1982_12
Patent number
US04362666

Reaction notes

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