Hydrochloric Acid → HCID 20515889, compound

HRID 1902225Notes

Reaction equation

HRID 1902225 reaction equation
[CH3:1][N:2]1[C:8](=[O:9])[C:7]2[N:10]=[CH:11][CH:12]=[CH:13][C:6]=2[N:5]2[CH:14]=[N:15][C:16]([C:17]([O:19]CC)=[O:18])=[C:4]2[CH2:3]1.[OH-].[Na+].O.Cl>C(O)C>[CH3:1][N:2]1[C:8](=[O:9])[C:7]2[N:10]=[CH:11][CH:12]=[CH:13][C:6]=2[N:5]2[CH:14]=[N:15][C:16]([C:17]([OH:19])=[O:18])=[C:4]2[CH2:3]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 13688161HCID 13688161, compound

Product 1

HCID 20515889HCID 20515889, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 1.61 g (5.6 mmol) of ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]pyrido[2,3-f][1,4]-diazepine-3-carboxylate, 0.33 g (8.2 mmol) of sodium hydroxide, 9 ml of water and 27 ml of ethyl alcohol is heated to boiling under reflux for 25 minutes. The mixture is treated with 8.2 ml of 1 N hydrochloric acid, the ethanol is removed by distillation, the residue is diluted with water and left to stand in an ice-bath for 1 hour. The precipitated material is filtered off under suction, washed with water and dried. There is obtained 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]pyrido[2,3-f][1,4]diazepine-3-carboxylic acid of melting point 292°-295°.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 25 minutes
  3. customthe ethanol is removed by distillation
  4. additionthe residue is diluted with water
  5. waitleft
  6. filtrationThe precipitated material is filtered off under suction
  7. washwashed with water
  8. customdried

Sources & evidence

ORD record
ord-a5d8fc51f349441787212de44f4cd7a3
Source dataset
uspto-grants-1982_12
Patent number
US04362732

Reaction notes

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