Sarcosine → HCID 13688150, compound

HRID 1902227Notes

Reaction equation

HRID 1902227 reaction equation
[C:1]12[C:7](=[N:8][CH:9]=[CH:10][CH:11]=1)[NH:6][C:5](=[O:12])[O:4][C:2]2=O.[NH:13]([CH2:15]C(O)=O)[CH3:14]>CS(C)=O>[CH3:14][N:13]1[C:2](=[O:4])[C:1]2[CH:11]=[CH:10][CH:9]=[N:8][C:7]=2[NH:6][C:5](=[O:12])[CH2:15]1

Participants

4

Reactant 2

HCID 1088SarcosineHCID 109865823-Azaisatoic anhydride

Product 1

HCID 13688150HCID 13688150, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

12.0 g (73.1 mmol) of 3-azaisatoic acid anhydride and 6.6 g (73.2 mmol) of sarcosine are stirred at 100° for 2.5 hours in 180 ml of dimethyl sulphoxide. The solvent is removed in a high vacuum and the oily residue is heated to 130° for about 4 hours. After cooling, the crystalline product is suspended in 150 ml of methanol. It is filtered off under suction, washed with methanol and dried. There is obtained 3,4-dihydro-4-methyl-2H-pyrido[2,3-e][1,4]diazepine-2,5(1H)-dione of melting point 245°-247°.

Workup

  1. customThe solvent is removed in a high vacuum
  2. temperaturethe oily residue is heated to 130° for about 4 hours
  3. temperatureAfter cooling
  4. filtrationIt is filtered off under suction
  5. washwashed with methanol
  6. customdried

Sources & evidence

ORD record
ord-1ec7d6da7a5c475c82d345c36d8625a2
Source dataset
uspto-grants-1982_12
Patent number
US04362732

Reaction notes

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