Sarcosine → HCID 13688150, compound

Participants

Reaction Steps

12.0 g (73.1 mmol) of 3-azaisatoic acid anhydride and 6.6 g (73.2 mmol) of sarcosine are stirred at 100° for 2.5 hours in 180 ml of dimethyl sulphoxide. The solvent is removed in a high vacuum and the oily residue is heated to 130° for about 4 hours. After cooling, the crystalline product is suspended in 150 ml of methanol. It is filtered off under suction, washed with methanol and dried. There is obtained 3,4-dihydro-4-methyl-2H-pyrido[2,3-e][1,4]diazepine-2,5(1H)-dione of melting point 245°-247°.

Provenance & Evidence