Hydrochloric Acid → HCID 178512696, compound

HRID 1902230Notes

Reaction equation

HRID 1902230 reaction equation
[C:1]([NH:3][C:4](=[NH:18])[CH2:5][CH2:6][S:7][CH2:8][C:9]1[N:10]=[C:11]([NH:14][C:15]([NH2:17])=[NH:16])[S:12][CH:13]=1)#[N:2].Cl.CC[O:22]CC>C(O)C.C(Cl)(Cl)Cl>[C:1]([NH:3][C:4](=[NH:18])[CH2:5][CH2:6][S:7][CH2:8][C:9]1[N:10]=[C:11]([NH:14][C:15]([NH2:17])=[NH:16])[S:12][CH:13]=1)(=[O:22])[NH2:2]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 178512333HCID 178512333, compound

Product 1

HCID 178512696HCID 178512696, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolvent2×HCID 6212ChloroformSolvent

Procedure

In a mixture of 15 ml of ethanol and 10 ml of chloroform was dissolved 0.5 g of N-cyano-3-[(2-guanidinothiazol-4-yl)-methylthio]propionamidine and after passing through the solution a dry hydrogen chloride gas for 1.5 hours under cooling by ice water, the reaction mixture was concentrated under reduced pressure. To the residue was added 10 ml of ethanol, the mixture was concentrated again under reduced pressure. The residue formed was dissolved in a small amount of ethanol and after adding thereto ether and allowing to stand overnight the mixture, the crystals deposited were collected by filtration to provide 0.55 g of N-carbamoyl-3-[(2-guanidinothiazol-4-yl)methylthio]propionamidine.di-hydrochloride. The product shows the following physicochemical properties:

Workup

  1. customfor 1.5 hours
  2. concentrationthe reaction mixture was concentrated under reduced pressure
  3. additionTo the residue was added 10 ml of ethanol
  4. concentrationthe mixture was concentrated again under reduced pressure
  5. customThe residue formed
  6. additionafter adding
  7. filtrationthe mixture, the crystals deposited were collected by filtration

Sources & evidence

ORD record
ord-7d894554e9774488904f87eda4cd19a1
Source dataset
uspto-grants-1982_12
Patent number
US04362736

Reaction notes

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