Hydrochloric Acid → HCID 149151126, compound

Participants

Reaction Steps

In a mixture of 20 ml of ethanol, 30 ml of chloroform, and 10 ml of methanol was dissolved 1.0 g of N-cyano-3-(2-methylguanidinothiazol-4-ylmethylthio)propionamidine and after cooling the solution to 0°-5° C. and passing therethrough a hydrogen chloride gas for one hour, the solvents were distilled off under reduced pressure. Then, the residue formed was recrystallized from ethanol to provide 1.2 g of N-carbamoyl-3-(2-methylguanidinothiazol-4-ylmethylthio)-propionamidine.di-hydrochloride showing a melting point of 180°-182° C.

Provenance & Evidence