Hydrochloric Acid → HCID 149151126, compound

HRID 1902232Notes

Reaction equation

HRID 1902232 reaction equation
C(Cl)(Cl)Cl.C[OH:6].[C:7]([NH:9][C:10](=[NH:25])[CH2:11][CH2:12][S:13][CH:14]([NH:20][C:21]([NH2:24])=[N:22][CH3:23])[C:15]1[N:16]=[CH:17][S:18][CH:19]=1)#[N:8].Cl>C(O)C>[C:7]([NH:9][C:10](=[NH:25])[CH2:11][CH2:12][S:13][CH:14]([NH:20][C:21]([NH2:24])=[N:22][CH3:23])[C:15]1[N:16]=[CH:17][S:18][CH:19]=1)(=[O:6])[NH2:8]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 6212ChloroformHCID 178485175HCID 178485175, compound

Product 1

HCID 149151126HCID 149151126, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a mixture of 20 ml of ethanol, 30 ml of chloroform, and 10 ml of methanol was dissolved 1.0 g of N-cyano-3-(2-methylguanidinothiazol-4-ylmethylthio)propionamidine and after cooling the solution to 0°-5° C. and passing therethrough a hydrogen chloride gas for one hour, the solvents were distilled off under reduced pressure. Then, the residue formed was recrystallized from ethanol to provide 1.2 g of N-carbamoyl-3-(2-methylguanidinothiazol-4-ylmethylthio)-propionamidine.di-hydrochloride showing a melting point of 180°-182° C.

Workup

  1. temperatureafter cooling the solution to 0°-5° C.
  2. distillationthe solvents were distilled off under reduced pressure
  3. customThen, the residue formed
  4. customwas recrystallized from ethanol

Sources & evidence

ORD record
ord-ed6c7dc161584949bf65e6314b03987f
Source dataset
uspto-grants-1982_12
Patent number
US04362736

Reaction notes

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