Hydrochloric Acid → HCID 178478798, compound

Participants

Reaction Steps

1 g of N-cyano-5-(2-guanidinothiazol-4-yl)pentanoamidine was suspended in a mixture of 20 ml of methanol and 30 ml of chloroform. Hydrogen chloride gas was passed through the suspension for 1.5 hour at -5° to 5° C. and the reaction solution was concentrated under reduced pressure. The oily residue was recrystallized from a mixture of methanol and ether containing a small amount of water to provide 1.1 g of N-carbamoyl-5-(2-guanidinothiazol-4-yl)pentanoamidine dihydrochloride monohydrate having a melting point of 148°-150° C.

Provenance & Evidence