Hydrochloric Acid → HCID 178478798, compound

HRID 1902239Notes

Reaction equation

HRID 1902239 reaction equation
[C:1]([NH:3][C:4](=[NH:18])[CH2:5][CH2:6][CH2:7][CH2:8][C:9]1[N:10]=[C:11]([NH:14][C:15]([NH2:17])=[NH:16])[S:12][CH:13]=1)#[N:2].[ClH:19].C[OH:21]>C(Cl)(Cl)Cl>[OH2:21].[ClH:19].[ClH:19].[C:1]([NH:3][C:4](=[NH:18])[CH2:5][CH2:6][CH2:7][CH2:8][C:9]1[N:10]=[C:11]([NH:14][C:15]([NH2:17])=[NH:16])[S:12][CH:13]=1)(=[O:21])[NH2:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 178512321HCID 178512321, compound

Product 1

HCID 178478798HCID 178478798, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

1 g of N-cyano-5-(2-guanidinothiazol-4-yl)pentanoamidine was suspended in a mixture of 20 ml of methanol and 30 ml of chloroform. Hydrogen chloride gas was passed through the suspension for 1.5 hour at -5° to 5° C. and the reaction solution was concentrated under reduced pressure. The oily residue was recrystallized from a mixture of methanol and ether containing a small amount of water to provide 1.1 g of N-carbamoyl-5-(2-guanidinothiazol-4-yl)pentanoamidine dihydrochloride monohydrate having a melting point of 148°-150° C.

Workup

  1. concentrationthe reaction solution was concentrated under reduced pressure
  2. customThe oily residue was recrystallized from a mixture of methanol and ether containing a small amount of water

Sources & evidence

ORD record
ord-6a8bd11c910e483ea49b0c59a2102f38
Source dataset
uspto-grants-1982_12
Patent number
US04362736

Reaction notes

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