Hydrochloric Acid → HCID 178468259, compound

HRID 1902240Notes

Reaction equation

HRID 1902240 reaction equation
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][CH2:11][CH2:12][CH2:13][C:14]#[N:15])[N:9]=1)[C:2]([NH2:4])=[NH:3].Cl.[CH2:17]([OH:19])[CH3:18]>C(Cl)(Cl)Cl>[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][CH2:11][CH2:12][CH2:13][C:14](=[NH:15])[O:19][CH2:17][CH3:18])[N:9]=1)[C:2]([NH2:4])=[NH:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 178510970HCID 178510970, compound

Product 1

HCID 178468259HCID 178468259, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

2 g of 2-guanidino-4-(4-cyanobutyl)thiazole was suspended in a mixture of 15 ml of ethanol and 25 ml of chloroform, and hydrogen chloride gas was passed through the solution under stirring at -5° to 5° C. for 2 hours. The resulting solution was allowed to stand at 5° C. for 4 days and the solvent was distilled away under reduced pressure. The residue was suspended in ethanol, and the suspension was poured into ice water containing 15 g of potasium carbonate. The precipitated crystals were collected by filtration washed with water and ether to provide 2.1 g of ethyl 5-(2-guanidinothiazol-4-yl)pentanoimidate having a melting point of 138°-139° C. ##STR64##

Workup

  1. waitto stand at 5° C. for 4 days
  2. distillationthe solvent was distilled away under reduced pressure
  3. additionthe suspension was poured into ice water containing 15 g of potasium carbonate
  4. filtrationThe precipitated crystals were collected by filtration
  5. washwashed with water and ether

Sources & evidence

ORD record
ord-fdfe753b24cb48c3baf23cfc6aa3c429
Source dataset
uspto-grants-1982_12
Patent number
US04362736

Reaction notes

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