反应详情

A solution of 4-[2-(2,2,2-trifluoroethyl)guanidino]-2-[4-(3-cyano-2-methylisothioureido)butylthio]pyrimidine (0.17 g.) in 33% w/v methylamine in ethanol was left at room temperature for 18 hours and then evaporated to dryness. The residue was triturated with ether and the insoluble solid collected and recrystallised from ethyl acetate to give 4-[2-(2,2,2-trifluoroethyl)guanidino]-2-[4-(2-cyano-3-methylguanidino)-butylthio]pyrimidine, m.p. 179°-180°.

1. customevaporated to dryness
2. customThe residue was triturated with ether
3. customthe insoluble solid collected
4. customrecrystallised from ethyl acetate