3-(3-AMino-1H-pyrazol-1-yl)propanenitrile → HCID 54298987, compound

HRID 1902303Notes

Reaction equation

HRID 1902303 reaction equation
[F:1][C:2]([F:8])([F:7])[CH2:3][N:4]=[C:5]=[S:6].[NH2:9][C:10]1[CH:14]=[CH:13][N:12]([CH2:15][CH2:16][C:17]#[N:18])[N:11]=1>C(#N)C>[F:1][C:2]([F:8])([F:7])[CH2:3][NH:4][C:5](=[S:6])[NH:9][C:10]1[CH:14]=[CH:13][N:12]([CH2:15][CH2:16][C:17]#[N:18])[N:11]=1

Participants

4

Reactant 2

HCID 122459333-(3-AMino-1H-pyrazol-1-yl)propanenitrileHCID 138837771,1,1-Trifluoro-2-isothiocyanatoethane

Product 1

HCID 54298987HCID 54298987, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

2,2,2-Trifluoroethylisothiocyanate (3.4 g.) was added to a solution of 3-amino-1-(2-cyanoethyl)-pyrazole (2.72 g.) in acetonitrile (10 ml.) and the solution left at room temperature for 18 hours. The mixture was evaporated to dryness and the residue recrystallised from ethanol to give 3-[3-(2,2,2-trifluoroethyl)thioureido]-1-(2-cyanoethyl)pyrazole, m.p. 164°-165°.

Workup

  1. customThe mixture was evaporated to dryness
  2. customthe residue recrystallised from ethanol

Sources & evidence

ORD record
ord-64eb143b8f6f40d9b506d8cf040ea338
Source dataset
uspto-grants-1982_12
Patent number
US04362728

Reaction notes

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