Thionyl Chloride → Myristoyl chloride

HRID 1902334Notes

Reaction equation

HRID 1902334 reaction equation
C(OCCC1C(=S(=O)=O)C(N)C(=CC=1)O[CH:11]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[C:12](O)=[O:13])C.S(Cl)([Cl:35])=O>C1C=CC=CC=1>[C:12]([Cl:35])(=[O:13])[CH2:11][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 131712894HCID 131712894, compound

Product 1

HCID 66986Myristoyl chlorideYield 100%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

4.5 g of intermediate B obtained by the example (b) was dissolved in 50 ml of benzene and stirred at the room temperature, and 7 ml of thionylchloride was then added therein. After stirred to make reflus for three hours, concentration was made, and 4.7 g (100%) of brown oil have been obtained.

Workup

  1. additionwas then added
  2. customfor three hours
  3. concentrationconcentration

Sources & evidence

ORD record
ord-6707d3ecf0c74586ae67c8496270ee9e
Source dataset
uspto-grants-1982_12
Patent number
US04362810

Reaction notes

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