Hydrazine hydrate (1:1) → HCID 12813042, compound

HRID 1902465Notes

Reaction equation

HRID 1902465 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[S:14][C:15]([C:19]([O:21]CC)=O)=[C:16]([CH3:18])[N:17]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].O.[NH2:25][NH2:26]>C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[S:14][C:15]([C:19]([NH:25][NH2:26])=[O:21])=[C:16]([CH3:18])[N:17]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 12813041HCID 12813041, compound

Product 1

HCID 12813042HCID 12813042, compoundYield 59%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 2-(3,4,5-trimethoxyphenyl)-4-methylthiazole-5-carboxylate prepared in Example 4 (6.2 g corresponding to its 0.02 mol), 6.1 g (0.1 mol) of hydrazine hydrate of purity of 82% and 150 ml of ethanol were heated for 6 hours at a temperature of 90° C. The crystals, which separated out after cooling the reaction mixture, were recrystallized from 95% aqueous ethanolic solution to obtain the object consisting of faintly yellow scale-like crystals, amounting to 3.8 g and melting at 179.5° to 181° C. at a yield of 59%.

Workup

  1. customThe crystals, which separated out
  2. temperatureafter cooling the reaction mixture
  3. customwere recrystallized from 95% aqueous ethanolic solution
  4. customto obtain the object

Sources & evidence

ORD record
ord-51919f7835404f2d84910756b0c3583f
Source dataset
uspto-grants-1982_12
Patent number
US04363813

Reaction notes

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