2-Amino-4-methylpyrimidine → HCID 54405718, compound

HRID 1902538Notes

Reaction equation

HRID 1902538 reaction equation
[I-].CS[C:4]1[S:5][CH2:6][C@@H:7]2[CH2:16][C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[CH2:9][N+:8]=12.[NH2:17][C:18]1[N:23]=[C:22]([CH3:24])[CH:21]=[CH:20][N:19]=1>>[CH3:24][C:22]1[CH:21]=[CH:20][N:19]=[C:18]([N:17]=[C:4]2[N:8]3[CH2:9][C:10]4[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=4[CH2:16][C@H:7]3[CH2:6][S:5]2)[N:23]=1

Participants

3

Reactant 2

HCID 79392-Amino-4-methylpyrimidineHCID 12874874(S)-3-Methylthio-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinolinium iodide

Product 1

HCID 54405718HCID 54405718, compoundYield 20.2%

Procedure

By following the procedure of Example 2, but using (S)-3-methylthio-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinolinium iodide (18.2 g) and 2-amino-4-methylpyrimidine (8.0 g) as the starting materials, (S)-3-[(4-methylpyrimidin-2-yl)imino]-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinoline (3.0 g) is obtained in the form of white crystals, m.p.=179° C.

Sources & evidence

ORD record
ord-46011a7651334a119daa2eac42c00169
Source dataset
uspto-grants-1982_12
Patent number
US04363909

Reaction notes

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