Aminopyridazine → HCID 22822249, compound

HRID 1902539Notes

Reaction equation

HRID 1902539 reaction equation
[I-].CS[C:4]1[S:5][CH2:6][C@@H:7]2[CH2:16][C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[CH2:9][N+:8]=12.[NH2:17][C:18]1[N:19]=[N:20][CH:21]=[CH:22][CH:23]=1>>[N:20]1[CH:21]=[CH:22][CH:23]=[C:18]([N:17]=[C:4]2[N:8]3[CH2:9][C:10]4[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=4[CH2:16][C@H:7]3[CH2:6][S:5]2)[N:19]=1

Participants

3

Reactant 2

HCID 230373AminopyridazineHCID 12874874(S)-3-Methylthio-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinolinium iodide

Product 1

HCID 22822249HCID 22822249, compoundYield 65.7%

Procedure

By following the procedure of Example 2, but using (S)-3-methylthio-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinolinium iodide (18.2 g) and 3-aminopyridazine (9.5 g) as the starting materials, (S)-3-(pyridazin-3-ylimino)-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinoline (9.3 g) is obtained in the form of light beige crystals, m.p.=140°-142° C.

Sources & evidence

ORD record
ord-b5e5f7cfa9fb4f85a38527e2142bce53
Source dataset
uspto-grants-1982_12
Patent number
US04363909

Reaction notes

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