HCID 12874874, compound → HCID 22822257, compound

HRID 1902541Notes

Reaction equation

HRID 1902541 reaction equation
[I-].CS[C:4]1[S:5][CH2:6][C@@H:7]2[CH2:16][C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[CH2:9][N+:8]=12.[NH2:17][C:18]1[C:26]2[C:21](=[CH:22][N:23]=[CH:24][CH:25]=2)[S:20][CH:19]=1>>[S:20]1[C:21]2=[CH:22][N:23]=[CH:24][CH:25]=[C:26]2[C:18]([N:17]=[C:4]2[N:8]3[CH2:9][C:10]4[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=4[CH2:16][C@H:7]3[CH2:6][S:5]2)=[CH:19]1

Participants

3

Reactant 2

HCID 12874874HCID 12874874, compoundHCID 15342498Thieno[2,3-c]pyridin-3-amine

Product 1

HCID 22822257HCID 22822257, compoundYield 68.2%

Procedure

By following the procedure of Example 2, but using (S)-3-methylthio-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinolinium iodide (10.1 g) and 3-aminothieno[2,3-c]pyridine (6.4 g) as the starting materials, (S)-3-[(thieno[2,3-c]pyrid-3-yl)imino]-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinoline (6.4 g) is obtained in the form of white crystals, m.p.=180° C.

Sources & evidence

ORD record
ord-11ed046b25b642b3ac6997b62f5442f2
Source dataset
uspto-grants-1982_12
Patent number
US04363909

Reaction notes

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