(S)-3-Methylthio-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinolinium iodide → HCID 22822248, compound

HRID 1902543Notes

Reaction equation

HRID 1902543 reaction equation
[I-].CS[C:4]1[S:5][CH2:6][C@@H:7]2[CH2:16][C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[CH2:9][N+:8]=12.[NH2:17][C:18]1[CH:19]=[CH:20][CH:21]=[C:22]2[C:27]=1[CH:26]=[N:25][CH:24]=[CH:23]2>>[CH:26]1[C:27]2[C:22](=[CH:21][CH:20]=[CH:19][C:18]=2[N:17]=[C:4]2[N:8]3[CH2:9][C:10]4[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=4[CH2:16][C@H:7]3[CH2:6][S:5]2)[CH:23]=[CH:24][N:25]=1

Participants

3

Reactant 2

HCID 12874874(S)-3-Methylthio-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinolinium iodideHCID 13927912Isoquinolin-8-amine

Product 1

HCID 22822248HCID 22822248, compoundYield 71.1%

Procedure

By following the procedure of Example 2, but using (S)-3-methylthio-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinolinium iodide (18.2 g) and 8-aminoisoquinoline (10.9 g) as the starting materials, (S)-3-(isoquinol-8-ylimino)-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinoline (11.8 g) is obtained in the form of pale yellow crystals, m.p.=206° C.

Sources & evidence

ORD record
ord-1f98494f16e94f9cb265c4983a0560ad
Source dataset
uspto-grants-1982_12
Patent number
US04363909

Reaction notes

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