Ammonia → HCID 13001827, compound

HRID 1902610Notes

Reaction equation

HRID 1902610 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]([CH3:12])[CH:10]=O)[CH:6]=[CH:7][CH:8]=1.[C:13]([O:19][CH3:20])(=[O:18])[CH2:14][C:15]([CH3:17])=O.[NH3:21]>C(O)C>[CH3:20][O:19][C:13]([C:14]1[CH:10]([CH:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=2)[CH3:12])[C:14]([C:13]([O:19][CH3:20])=[O:18])=[C:15]([CH3:17])[NH:21][C:15]=1[CH3:17])=[O:18]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 7757Methyl acetoacetateHCID 13001826HCID 13001826, compound

Product 1

HCID 13001827HCID 13001827, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

16.4 g of 2-(3-methoxyphenyl)-propionaldehyde, 23.2 g of methyl acetoacetate and 2.1 ml of NH3 (33% strength) in 50 cm3 of ethanol were heated under reflux for 4 hours. After the mixture had cooled, the product crystallised out. It was purified by recrystallisation from ethanol.

Workup

  1. temperatureunder reflux for 4 hours
  2. temperatureAfter the mixture had cooled
  3. customthe product crystallised out
  4. customIt was purified by recrystallisation from ethanol

Sources & evidence

ORD record
ord-480efe456c0c4393bbdf1dc3ed32466d
Source dataset
uspto-grants-1982_12
Patent number
US04364952

Reaction notes

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