Diethyl (ethoxymethylene)malonate → HCID 12892053, compound

HRID 1902634Notes

Reaction equation

HRID 1902634 reaction equation
[N:1]1[CH:2]=[CH:3][N:4]2[C:8]3[CH:9]=[C:10]([NH2:13])[CH:11]=[CH:12][C:7]=3[S:6][C:5]=12.C(O[CH:17]=[C:18]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[C:19]([O:21][CH2:22][CH3:23])=[O:20])C>O(CC)CC>[N:1]1[CH2:2][CH2:3][N:4]2[C:8]3[CH:9]=[C:10]([NH:13][CH:17]=[C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[C:24]([O:26][CH2:27][CH3:28])=[O:25])[CH:11]=[CH:12][C:7]=3[S:6][C:5]=12

Participants

4

Reactant 2

HCID 6871Diethyl (ethoxymethylene)malonateHCID 20514572HCID 20514572, compound

Product 1

HCID 12892053HCID 12892053, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
110 °C

Procedure

A mixture of 5.5 parts of imidazo[2,1-b]benzothiazol-6-amine and 7.5 parts of diethyl 2-(ethoxymethylene)propanedioate is stirred for 30 minutes at 110° C. The solid product is suspended in 1,1'-oxybisethane. It is filtered off and dried, yielding 10 parts (95%) of diethyl 2-[(2,3-dihydroimidazo[2,1-b]benzothiazol-6-yl)aminomethylene]propanedioate; mp. 140° C.

Workup

  1. filtrationIt is filtered off
  2. customdried

Sources & evidence

ORD record
ord-e8dff95fd553423c9206ff1f4ff6c0e0
Source dataset
uspto-grants-1982_12
Patent number
US04364942

Reaction notes

Loading…