Acetic Acid → HCID 12873988, compound

HRID 1902640Notes

Reaction equation

HRID 1902640 reaction equation
[N:1]1[CH:2]=[CH:3][N:4]2[C:8]3[CH:9]=[C:10]([NH2:13])[CH:11]=[CH:12][C:7]=3[S:6][C:5]=12.C(O)(=O)C.[O-:18][C:19]#[N:20].[K+].[OH-].[NH4+]>O>[N:1]1[CH2:2][CH2:3][N:4]2[C:8]3[CH:9]=[C:10]([NH:13][C:19]([NH2:20])=[O:18])[CH:11]=[CH:12][C:7]=3[S:6][C:5]=12

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 14923Ammonium HydroxideHCID 11378442Potassium cyanateHCID 20514572HCID 20514572, compound

Product 1

HCID 12873988HCID 12873988, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

To a stirred mixture of 3 parts of imidazo[2,1-b]benzothiazol-6-amine, 16 parts of acetic acid and 32 parts of water is added dropwise a solution of 1.54 parts of potassium cyanate in 32 parts of water (slightly exothermic reaction). Upon completion, stirring is continued overnight at room temperature. The reaction mixture is alkalized with ammonium hydroxide. Upon stirring, the product is precipitated. It is filtered off and dried, yielding 3 parts of N-(2,3-dihydroimidazo[2,1-b]benzothiazol-6-yl)urea; mp.+300° C.

Workup

  1. customslightly exothermic reaction)
  2. stirringUpon stirring
  3. customthe product is precipitated
  4. filtrationIt is filtered off
  5. customdried

Sources & evidence

ORD record
ord-1dd4f8bb6a8348c0b08dbff325afcf84
Source dataset
uspto-grants-1982_12
Patent number
US04364942

Reaction notes

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