Hydrogen Bromide → HCID 20514582, compound

HRID 1902642Notes

Reaction equation

HRID 1902642 reaction equation
C([O:3][C:4]1[CH:15]=[CH:14][C:7]2[N:8]3[CH2:13][CH2:12][N:11]=[C:9]3[S:10][C:6]=2[CH:5]=1)C.[BrH:16]>C(O)(=O)C>[BrH:16].[N:11]1[CH2:12][CH2:13][N:8]2[C:7]3[CH:14]=[CH:15][C:4]([OH:3])=[CH:5][C:6]=3[S:10][C:9]=12

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 12892027HCID 12892027, compound

Product 1

HCID 20514582HCID 20514582, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 10 parts of 7-ethoxy-2,3-dihydroimidazo[2,1-b]benzothiazole and 150 parts of hydrobromic acid solution 48% in glacial acetic acid is stirred and refluxed overnight. The reaction mixture is evaporated. The solid residue is washed with ethanol and crystallized from ethanol 80%. The product is filtered off and dried, yielding 8 parts of 2,3-dihydroimidazo[2,1-b]benzothiazol-7-ol monohydrobromide; mp. 259.9° C.

Workup

  1. temperaturerefluxed overnight
  2. customThe reaction mixture is evaporated
  3. washThe solid residue is washed with ethanol
  4. customcrystallized from ethanol 80%
  5. filtrationThe product is filtered off
  6. customdried

Sources & evidence

ORD record
ord-458a8a85e55246eb94021cb19149bbd2
Source dataset
uspto-grants-1982_12
Patent number
US04364942

Reaction notes

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