Piperazine → 2-Piperazin-1-YL-quinoxaline

HRID 1902675Notes

Reaction equation

HRID 1902675 reaction equation
Cl[C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>>[N:12]1([C:2]2[CH:11]=[N:10][C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=2)[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 2389382-Chloroquinoxaline2×

Product 1

HCID 118205602-Piperazin-1-YL-quinoxaline

Procedure

2-(1-Piperazinyl)quinoxaline is prepared from 2-chloroquinoxaline by reaction with piperazine in a manner similar to the preparation of 2-(1-piperazinyl)quinoxalines described in British Pat. No. 1,440,722, issued June 23, 1976 and assigned to Merck & Co. The preparation of 2-chloroquinoxaline is described at Gowenlock et al., J. Chem Soc. 1945: 622.

Sources & evidence

ORD record
ord-789352400b014962abdd8cec2bcdbfaa
Source dataset
uspto-grants-1982_12
Patent number
US04364954

Reaction notes

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