反应详情

A mixture of 5.15 g of ethyl 2-(p-formylphenyl)propionate, 4.5 g of pyrrolidinocyclohexene and 20 ml of benzene was heated under reflux for 18 hours. After cooling, the reaction mixture was admixed with a mixture of 5 ml of conc. hydrochloric acid and 5 ml of water under ice-cooling and then stirred at room temperature overnight. 100 ml of benzene were added thereto, the organic layer was separated and then washed with water. After drying over anhydrous sodium sulfate, the benzene was distilled off to leave an oily substance. The substance was distilled under reduced pressure to afford 2.3 g of the desired product as a yellow oily substance having a boiling point of 160°-170° C./0.3 mmHg (bath temp.).

1. temperaturewas heated
2. temperatureunder reflux for 18 hours
3. temperatureAfter cooling
4. temperaturecooling
5. customthe organic layer was separated
6. washwashed with water
7. dry with materialAfter drying over anhydrous sodium sulfate
8. distillationthe benzene was distilled off
9. customto leave an oily substance
10. distillationThe substance was distilled under reduced pressure