HCID 70545483, compound → HCID 86737714, compound

HRID 1902851Notes

Reaction equation

HRID 1902851 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:9][C:8]([CH2:10][S:11][CH2:12][CH2:13][NH:14][C:15]([NH:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][NH2:33])=[CH:16][N+:17]([O-:19])=[O:18])=[CH:7][CH:6]=1)[CH3:3].[O:34]1[CH:38]=[CH:37][CH:36]=[C:35]1[CH2:39][S:40][CH2:41][CH2:42][NH:43][C:44](SC)=[CH:45][N+:46]([O-:48])=[O:47]>C(OCC)(=O)C>[CH3:1][N:2]([CH2:4][C:5]1[O:9][C:8]([CH2:10][S:11][CH2:12][CH2:13][NH:14][C:15]([NH:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][NH:33][C:44]([NH:43][CH2:42][CH2:41][S:40][CH2:39][C:35]2[O:34][CH:38]=[CH:37][CH:36]=2)=[CH:45][N+:46]([O-:48])=[O:47])=[CH:16][N+:17]([O-:19])=[O:18])=[CH:7][CH:6]=1)[CH3:3]

Participants

4

Reactant 2

HCID 70545483HCID 70545483, compoundHCID 70546016HCID 70546016, compound

Product 1

HCID 86737714HCID 86737714, compoundYield 69.8%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of N-[1-[[2-[[5-[(dimethylamino)methyl]-2-furanylmethyl]thio]ethyl]amino]-2-nitroethenyl]-1,12-dodecanediamine (0.8 g.) and N-2-[[(2-furanyl)methyl]thio]ethyl-1-(methylthio)-2-nitroethenamine (0.57 g.) in ethyl acetate (8 ml.) was evaporated and the residue heated at 98°-100° for 2 hours. The oily residue was dissolved in methanol (10 ml.) and evaporated to dryness (×2). The oily residue was triturated with ethyl acetate (30 ml.), the solid which separated was washed with ethyl acetate and dried to give the title compound (0.82 g.), m.p. 69°-72°

Workup

  1. customwas evaporated
  2. temperaturethe residue heated at 98°-100° for 2 hours
  3. dissolutionThe oily residue was dissolved in methanol (10 ml.)
  4. customevaporated to dryness (×2)
  5. customThe oily residue was triturated with ethyl acetate (30 ml.)
  6. customthe solid which separated
  7. washwas washed with ethyl acetate
  8. customdried

Sources & evidence

ORD record
ord-f793239e7bad44aeb6838719220eaed3
Source dataset
uspto-grants-1982_12
Patent number
US04366164

Reaction notes

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