Isobutylamine → HCID 178448425, 화합물

HRID 1902857노트

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HRID 1902857 반응식
Cl.CS[C:4]1[NH:5][CH2:6][C:7]([CH3:10])([CH3:9])[N:8]=1.[CH3:11][CH:12]([CH3:15])[CH2:13][NH2:14].ClC1C=[CH:23][C:20]([CH2:21][NH2:22])=[CH:19]C=1.[N:25](=[C:27]([C:33]#[N:34])[C:28]([O:30]CC)=[O:29])[OH:26].S(S([O-])(=O)=O)([O-])(=O)=O.[Na+].[Na+].[OH-].[Na+]>C(O)=O>[NH2:34][C:33]1[N:14]([CH2:13][CH:12]([CH3:15])[CH3:11])[C:4]2[N:5]([CH2:6][C:7]([CH3:10])([CH3:9])[N:8]=2)[C:28](=[O:29])[C:27]=1[N:25]=[O:26].[CH3:23][CH:20]([CH3:19])[CH2:21][N:22]1[C:33]2[NH:34][CH:11]=[N:25][C:27]=2[C:28](=[O:30])[N:5]2[CH2:6][C:7]([CH3:10])([CH3:9])[N:8]=[C:4]12

참가 물질

8

반응물 6

HCID 6558IsobutylamineHCID 14798Sodium HydroxideHCID 660364-ChlorobenzylamineHCID 146045Sodium dithionateHCID 6399078Ethyl 2-cyano-2-(hydroxyimino)acetateHCID 1785034432-Methylthio-4,4-dimethyl-2-imidazoline hydrochloride

생성물 1

HCID 178448425HCID 178448425, 화합물

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

6,7-DIHYDRO-4-(2-METHYLPROPYL)-6,6-DIMETHYL-3H-IMIDAZO[1,2-a]PURIN-9(4H)-ONE 7-Amino-2,3-dihydro-2,2-dimethyl-8-(2-methylpropyl)-6-nitrosoimidazo[1,2-a]pyrimidin-5(8H)-one was prepared by reaction of the 2-methylthio-4,4-dimethyl-2-imidazoline hydrochloride with 2-methylpropylamine according to the method of Procedure 103 by substitution of the latter for p-chlorobenzylamine. The reaction product from this step was then condensed with ethyl oximinocyanoacetate as described in Procedure 103. The resulting nitroso compound was then reduced with sodium dithionate in formic acid and the resulting formylamino compound was cyclized with dilute aqueous sodium hydroxide according to Procedure 100.

출처 및 근거

ORD 기록
ord-4b1607b80beb4b8eacb663c19608eb6f
출처 데이터셋
uspto-grants-1982_12
특허 번호
US04366156

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