反应详情

A solution of 62.4 g of 2,4-dichloro-3-nitroanisole in 750 ml of ethanol is treated with 19 g of Raney-nickel and hydrogenated for 8 hours. The obtained solution is filtered and evaporated in vacuo. The residue is taken up in methylene chloride and the solution is washed with a dilute sodium carbonate solution. After drying the organic phase over sodium sulfate and evaporating in vacuo, there is obtained 2,6-dichloro-3-methoxyaniline of boiling point 84° (0.1 Torr).

1. filtrationThe obtained solution is filtered
2. customevaporated in vacuo
3. washthe solution is washed with a dilute sodium carbonate solution
4. dry with materialAfter drying the organic phase over sodium sulfate
5. customevaporating in vacuo