Hydrochloric Acid → HCID 178490737, compound

HRID 1902868Notes

Reaction equation

HRID 1902868 reaction equation
C([O:8][N:9]1[CH2:13][CH2:12][NH:11][C:10]1=[N:14][C:15]1[C:20]([Cl:21])=[CH:19][CH:18]=[C:17]([O:22][CH3:23])[C:16]=1[Cl:24])C1C=CC=CC=1.Cl>C(O)C.[Pd]>[ClH:21].[Cl:24][C:16]1[C:17]([O:22][CH3:23])=[CH:18][CH:19]=[C:20]([Cl:21])[C:15]=1[N:14]=[C:10]1[NH:11][CH2:12][CH2:13][N:9]1[OH:8]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178490739HCID 178490739, compound

Product 1

HCID 178490737HCID 178490737, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 20.14 g of 1-(benzyloxy)-2-(2,6-dichloro-3-methoxyphenyl)imino-imidazolidine in 100 ml of ethanol is treated with 6.5 ml of concentrated hydrochloric acid and 1.0 g of palladium/carbon and hydrogenated at room temperature. After 2 hours, the solution is filtered and the filtrate is evaporated in vacuo. The residual material is taken up in acetone and heated to boiling under reflux. There is obtained 2-[(2,6-dichloro-3-methoxyphenyl)imino]-1-hydroxyimidazolidine hydrochloride of melting point 215°-217°.

Workup

  1. filtrationthe solution is filtered
  2. customthe filtrate is evaporated in vacuo
  3. temperatureheated
  4. temperatureunder reflux

Sources & evidence

ORD record
ord-247cb87c8f5f44d48fc45be1782ca667
Source dataset
uspto-grants-1982_12
Patent number
US04366160

Reaction notes

Loading…