Water → L-Phenylalanine

HRID 1902878Notes

Reaction equation

HRID 1902878 reaction equation
Cl.[NH2:2][CH:3]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:4](N)=[O:5].[OH2:14]>>[NH2:2][C@H:3]([C:4]([OH:14])=[O:5])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 962WaterHCID 12699297Phenylalaninamide--hydrogen chloride (1/1)

Product 1

HCID 6140L-PhenylalanineYield 50%

Procedure

The treatment of a solution at 5% of 2-amino-3-phenyl propionamide hydrochloride in water (pH included between 6.5 and 8.5) is effected by a suspension of cells of strain A4 at 20 to 40 g of dry matter per liter. One obtains quantitatively L-phenylalanine (50%) and the corresponding D-amide (50%). This D amide can either be hydrolized in D-phenylalanine by action of strain R 312 (CBS 717.73) or racemized and recycled in regard to preparation of L-phenyl-alanine.

Sources & evidence

ORD record
ord-517ea6aaa13d48dfbd1b39ae01c6d836
Source dataset
uspto-grants-1982_12
Patent number
US04366250

Reaction notes

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