反应详情

366 mg (1.05 mmoles) of 3-methyl-7-phenylacetamido-3-cephem-4-carboxylic acid-1-oxide were silylated in one hour at room temperature by stirring in 25 ml of dichloromethane with 208 mg (1.43 mmoles) of N-methyl-N-trimethylsilylacetamide. The clear solution obtained was cooled in an ice-bath and bromination was carried out in half an hour using 282 mg (1.58 mmoles) of N-bromosuccinimide as the brominating agent to obtain a 44% yield of trimethylsilyl 3-bromomethyl-7-phenylacetamido-3-cephem-4-carboxylate-1-oxide.

1. customThe clear solution obtained
2. temperaturewas cooled in an ice-bath
3. waitbromination was carried out in half an hour