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HRID1902913

反应详情

EQUATION

反应方程式

HRID 1902913 的结构方程式

REACTANTS

反应物

3
结构：O=C1CCC(=O)N1Br
HCID67184

1-Bromopyrrolidine-2,5-dione

C4H4BrNO2

结构：CC(=O)N(C(C)=O)[Si](C)(C)C
HCID14340951

未命名化合物

结构：CC1=C(C(=O)O)N2C(=O)C(NC(=O)Cc3ccccc3)[C@H]2S(=O)C1
HCID70485748

未命名化合物

PRODUCTS

生成物

1
结构：C[Si](C)(C)OC(=O)C1=C(CBr)CS(=O)[C@@H]2C(NC(=O)Cc3ccccc3)C(=O)N12
HCID70463777

未命名化合物

收率 47%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

A clear solution was obtained after refluxing a suspension of 371.8 mg (1.07 mmoles) of 3-methyl-7-phenylacetamido-3-cephem-4-carboxylic acid-1-oxide and 284.7 mg (1.65 mmoles) of N-trimethylsilyldiacetamide in 40 ml of dichloromethane for 5 minutes and it was cooled in an ice-bath and brominated in half an hour with 290.2 mg (1.63 mmoles) of N-bromosuccinimide to obtain a 47% yield of trimethylsilyl 3-bromomethyl-7-phenylacetamido-3-cephem-4-carboxylate-1-oxide.

WORKUP

后处理

  1. customA clear solution was obtained
  2. temperatureafter refluxing
  3. temperatureit was cooled in an ice-bath